Montelukast, a cysteinyl leukotriene receptor antagonist, exerts local antinociception in animal model of pain through the L-arginine/nitric oxide/cyclic GMP/KATP …

E Alizamani, B Ghorbanzadeh… - International Journal …, 2021 - Taylor & Francis
E Alizamani, B Ghorbanzadeh, R Naserzadeh, MT Mansouri
International Journal of Neuroscience, 2021•Taylor & Francis
Objective The leukotrienes are inflammatory mediators. In the present study, the analgesic
role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible
involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARγ receptors was
assessed in the formalin test in rats. Methods and results The local administration of
montelukast into the hind paw produced dose-related analgesia during both phases of the
formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide …
Objective
The leukotrienes are inflammatory mediators. In the present study, the analgesic role of local montelukast, a cysteinyl leukotriene receptor antagonist, and the possible involvement of L-arginine/NO/cGMP/KATP channel pathway and PPARγ receptors was assessed in the formalin test in rats.
Methods and results
The local administration of montelukast into the hind paw produced dose-related analgesia during both phases of the formalin test. Furthermore, pre-treatment with L-NAME, methylene blue, and glibenclamide prevented montelukast (10 μg/paw)-induced antinociception in both early and late phases of the test. Moreover, the local L-arginine and diazoxide before the sub-effective dose of montelukast (3 μg/paw) produced an analgesic effect. Also, local GW-9662 blocked antinociception induced by montelukast plus pioglitazone (10 μg/paw).
Conclusion
In conclusion, montelukast produced peripheral analgesia through PPARγ receptors and activation of the L-arginine/NO/cGMP/KATP channel pathway, with potential for a new topical analgesic drug.
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